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Human Accelerated Regions (HARs)

These 202 genomic regions were described in two papers:

Pollard et al. (2006). Forces shaping the fastest evolving regions in the
human genome
, PLoS Genetics, 2(10). (Link to PLoS)

Pollard et al. (2006). An RNA gene expressed during cortical development
evolved rapidly in humans
, Nature, 443, pp.167-172. (Link to Nature)

Definitions of the column headers are given at the bottom of the table.

NameCoordinatesLocationLast BandmRNAESTEvofold
Structure
Evofold
Statistic
Evofold
Pvalue
Human
Subs
Chimp
Subs
LRT
Statistic
LRT
Pvalue
Index of
Dispersion
Statistic
Index of
Dispersion
Pvalue
HAR1chr20:61203966-61204071intergenicYESYESYESYES5.50.0050.13140.010260.310.000011.280.1117
HAR2chr2:236556014-236556132intronicNONONONONANA0.10050.000835.620.000013.750.0426
HAR3chr7:1979228-1979333intronicYESNONONONANA0.05650.000514.400.00006.950.1648
HAR4chr16:71686982-71687100intergenicNONONOYES00.3090.04190.000213.880.00005.900.0471
HAR5chr12:844471-844816intronicYESNOYESNONANA0.02410.001310.360.00008.260.0000
HAR6chr16:76916722-76917050intronicNONONOYES00.7920.01520.00329.880.00003.720.0007
HAR7chr12:59202865-59202966intergenicNONONONONANA0.03910.00039.640.00002.360.5418
HAR8chr7:38997744-38997976intronicNONONOYES0.50.1730.01710.00449.570.00002.090.0227
HAR9chr20:40958988-40959210intronicNONONOYES0.250.3620.01790.00019.290.00004.560.0227
HAR10chr3:60900834-60900936intronicNONONONONANA0.03870.00029.170.00004.600.1868
HAR11chrX:32904477-32904674intronicNONONOYES00.5030.02010.00028.980.00003.850.0091
HAR12chr5:158135486-158135617intronicNONOYESNONANA0.02260.00018.980.00003.460.1388
HAR13chr2:177569964-177570192intergenicNONONOYES-0.50.1350.01740.00018.920.00004.620.0978
HAR14chr11:130470640-130470857intergenicYESNONONONANA0.02310.00058.910.00004.960.0010
HAR15chr13:72012985-72013309intergenicNONONONONANA0.01530.00338.650.00723.670.0122
HAR16chr2:147183192-147183607intergenicNONOYESYES0.50.3480.00970.00028.540.01624.010.0000
HAR17chr6:51401873-51402020intergenicNONONOYES1.250.0110.02020.00698.510.02042.160.4888
HAR18chr15:34178827-34179079intergenicNONONOYES1.750.2960.01990.00048.500.02044.970.0019
HAR19chr2:118783783-118783891intergenicNONONOYES0.250.3340.03660.00988.480.02592.860.1415
HAR20chr4:23552023-23552258intronicNONONONONANA0.02120.00028.140.02595.520.0050
HAR21chr14:32596701-32596801intronicNONOYESNONANA0.02960.00017.940.02592.120.1400
HAR22chr10:10514272-10514383intergenicNONONOYES0.250.0640.02670.00907.880.02592.350.5418
HAR23chr4:156106714-156106831codingNOYESYESNONANA0.03370.00027.790.02594.430.0704
HAR24chr7:26654309-26654572intronicNONONOYES0.250.340.01520.00027.780.02594.270.0039
HAR25chr4:182647070-182647210intergenicNONONONONANA0.02870.00777.720.02593.110.0367
HAR26chr12:93431437-93431550intergenicNONONONONANA0.03500.00047.480.02594.060.0780
HAR27chr4:181600521-181600743intergenicNONONOYES0.50.0350.02240.00027.430.02595.610.0481
HAR28chr4:62506874-62506977intronicNONONONONANA0.02870.00027.420.02591.230.2731
HAR29chr5:3831280-3831396intergenicYESNONONONANA0.03420.00877.360.02593.380.3448
HAR30chr1:61161406-61161510intergenicNONONONONANA0.02860.00027.130.02593.600.1849
HAR31chr7:69092670-69092828intronicNONONOYES00.2310.01880.00027.010.02593.040.0462
HAR32chr16:72096475-72096585intergenicNONONOYES-0.250.7010.02690.00026.990.02593.260.0780
HAR33chr22:45561741-45561856intronicNONONOYES0.50.020.03440.00036.980.02594.560.0391
HAR34chr9:13741079-13741218intergenicNONONONONANA0.02090.00126.910.02593.140.0227
HAR35chr16:78713184-78713305intergenicNONONOYES0.250.290.02450.00036.830.02592.980.0227
HAR36chr2:118525792-118525951intergenicNONONOYES0.250.2330.01250.00016.800.02592.170.0333
HAR37chr2:157665493-157665665intergenicNONONOYES0.250.2210.01730.00016.780.02593.150.0462
HAR38chr3:4749794-4749893codingNOYESYESNONANA0.04010.01056.740.02593.330.3479
HAR39chr4:181045324-181045543intergenicNONONONONANA0.01810.00016.720.02594.300.0049
HAR40chr11:113604985-113605403intronicNONONOYES0.750.4770.01210.00036.610.02594.800.0006
HAR41chr5:164665146-164665339intergenicNONONOYES0.250.0240.02070.01056.570.02592.680.1770
HAR42chr18:74291168-74291322intergenicYESNONONONANA0.02600.00066.550.02594.120.0171
HAR43chr1:49065863-49065980intronicNONONONONANA0.02540.00016.530.02593.320.0373
HAR44chr3:60307956-60308104intronicNONONOYES00.4850.02030.00036.510.02593.200.0068
HAR45chrX:24708550-24708710intronicNONONONONANA0.02480.00026.510.02594.250.0700
HAR46chr6:50309962-50310074intergenicNONONONONANA0.02830.00836.470.02824.490.0109
HAR47chr18:28605292-28605401intronicNONOYESNONANA0.02740.00936.420.03081.300.3104
HAR48chr11:79399570-79399751intergenicNONONONONANA0.01650.00026.350.03242.700.0036
HAR49chr7:8719669-8719814intergenicNONONONONANA0.02050.00016.280.03753.120.0349
HAR50chr4:106325115-106325226intergenicNONONOYES00.120.02680.00906.150.06522.540.5107
HAR51chr16:62407850-62407949intergenicNONONONONANA0.02990.00016.090.06643.490.1648
HAR52chr9:78713209-78713448intergenicNONONOYES0.250.1480.01660.00016.080.06644.680.0227
HAR53chr13:39559410-39559512intergenicNONONOYES00.4630.02910.00026.030.06643.590.0688
HAR54chr1:104532754-104532862intergenicNONONONONANA0.02740.01856.020.06641.850.5978
HAR55chr9:20794584-20794807intronicNONOYESNONANA0.01900.00586.000.06642.710.0000
HAR56chr10:130734160-130734346intergenicYESNONONONANA0.02330.00265.980.06643.000.0000
HAR57chr12:59712715-59712834intergenicNONONOYES00.0870.02500.00015.970.06643.660.0370
HAR58chr6:92228005-92228107intergenicNONONONONANA0.02900.00025.930.06643.190.0734
HAR59chr13:93228226-93228326intronicNONONONONANA0.02960.00025.910.06643.480.1644
HAR60chr5:67469387-67469534intergenicNONONONONANA0.01900.00145.890.06641.390.0649
HAR61chr6:51100120-51100261intergenicNONONONONANA0.02110.00035.880.06642.900.0119
HAR62chr4:25884505-25884637intergenicNONONOYES-0.50.2510.02250.00025.870.06643.120.0373
HAR63chr2:19583281-19583424intergenicNONONONONANA0.02080.00025.850.06643.100.0050
HAR64chr9:125764689-125764849intronicNONOYESYES00.8950.01870.00635.850.06642.490.1770
HAR65chr2:146856894-146857159intergenicNONONOYES-0.250.7130.01130.00025.810.06642.910.0013
HAR66chr1:161082008-161082150intergenicNONONONONANA0.02090.00015.790.06643.210.0102
HAR67chr13:71271583-71271698intronicNONONOYES00.5910.01720.00015.780.06642.310.0477
HAR68chr4:98476236-98476421intergenicNONONOYES00.0890.02700.01125.760.06643.420.1928
HAR69chr7:66973417-66973587intergenicNONONOYES1.250.0370.01790.00065.730.06642.910.0012
HAR70chr4:182984868-182984991intergenicNONONOYES00.1640.02440.00845.710.06642.360.4474
HAR71chr1:214332542-214332660intronicNONONONONANA0.02510.00025.710.06643.000.0801
HAR72chr22:47818237-47818398intergenicYESNONONONANA0.01850.00035.700.06642.850.0171
HAR73chr6:99052937-99053287intergenicNONONOYES0.750.030.00850.00005.700.06643.190.0000
HAR74chr1:174064452-174064646intergenicNONONONONANA0.02050.00025.690.06644.140.0046
HAR75chr5:166867917-166868056intergenicNONONONONANA0.02140.00015.680.06643.610.0692
HAR76chrX:85271907-85272271intronicNONONOYES0.50.1580.01040.00065.570.06642.070.0011
HAR77chr11:8335232-8335442intergenicNONONOYES0.250.5020.01930.00065.520.06644.100.0036
HAR78chr15:93249477-93249599intergenicNONONOYES0.50.0410.02470.00055.480.06643.480.0203
HAR79chr4:139136485-139136582intergenicNONONOYESNA10.02850.00225.480.06641.280.5471
HAR80chr2:118783577-118783767intergenicNONONOYES00.7880.01660.01155.470.06641.640.0007
HAR81chr15:58121271-58121425intergenicNONOYESYES-0.50.860.01940.01305.460.06641.810.1884
HAR82chr9:16006783-16006884intergenicNONOYESNONANA0.02940.01005.450.06642.330.5107
HAR83chr16:77482901-77483029intronicNOYESNOYES0.750.120.02330.00035.390.06643.250.0805
HAR84chr2:212906070-212906312intronicNONONOYES00.8680.01230.00015.340.06643.570.1257
HAR85chr4:182956597-182956997intergenicNONONOYES10.5280.01020.00535.310.06642.020.0004
HAR86chr5:164480841-164480978intergenicNONONONONANA0.02170.00015.290.06643.280.0652
HAR87chr16:81400854-81400955intronicNONONONONANA0.02930.00025.280.06643.330.0978
HAR88chr5:76926988-76927188intergenicNONONONONANA0.02020.00055.280.06643.950.0023
HAR89chr14:33135309-33135561intronicNONONOYESNA10.01180.00015.220.06642.850.0046
HAR90chr17:53030634-53030869intronicNONONOYES0.250.1050.01690.00025.200.06643.710.0024
HAR91chr7:26626650-26626749intronicNONONOYESNA10.01990.00015.190.06642.060.1271
HAR92chr15:59780128-59780345intergenicNONONONONANA0.01380.00475.190.06641.960.0171
HAR93chr8:20879134-20879268intergenicNONONONONANA0.01480.00015.190.06642.230.0683
HAR94chr11:116838425-116838789intronicNONONONONANA0.01100.01105.180.06642.370.0096
HAR95chr13:68568937-68569072intergenicNONONONONANA0.02200.00015.170.06643.560.0183
HAR96chr14:32486755-32486990intronicNONONOYESNA10.00860.00035.160.06641.970.0037
HAR97chr4:11547241-11547343intergenicNONONOYES2.50.0010.01930.00025.140.06642.170.3104
HAR98chr1:3112911-3113046intronicNONOYESYESNA10.02210.00015.090.06643.800.0458
HAR99chr14:82789255-82789360intergenicNONONONONANA0.01880.00025.070.06642.040.0978
HAR100chr1:57778534-57778636intronicNONOYESYESNA10.01940.00015.070.06642.270.2212
HAR101chr18:70640025-70640164intronicNONONONONANA0.02160.00025.060.06643.860.0495
HAR102chr13:93257055-93257288intronicNONONOYES0.50.2070.01280.00435.060.06642.280.0665
HAR103chr2:23036743-23036913intergenicNONOYESNONANA0.01750.00015.060.06643.320.0066
HAR104chr4:1581106-1581451intergenicYESNONOYES00.8790.01740.00025.020.06646.510.0006
HAR105chr13:105155705-105155820intergenicNONOYESYESNA10.02590.00034.970.06641.160.0744
HAR106chr18:33548745-33548916intergenicNONONONONANA0.01900.00194.970.06642.600.0000
HAR107chr1:88357451-88357651intergenicNONONOYES00.1020.01480.00014.950.06642.880.0068
HAR108chr16:72074171-72074325intergenicNONONOYESNA10.01280.00014.950.06641.920.0198
HAR109chr9:24441492-24441666intergenicNONONONONANA0.01710.00584.940.06642.000.0227
HAR110chr4:139142781-139142896intergenicNONONOYESNA10.01720.00874.930.06641.310.1415
HAR111chr6:98405251-98405520intergenicNONONOYES0.50.0990.01490.00014.930.06644.880.0391
HAR112chr3:584533-584805intergenicYESNONONONANA0.01480.00764.930.06642.970.0009
HAR113chr7:90678268-90678414intergenicNONONONONANA0.02030.00014.890.06643.120.0172
HAR114chr5:123543625-123543724intergenicNONONONONANA0.01990.00014.880.06642.230.0655
HAR115chr2:166176222-166176322intergenicNONONONONANA0.02960.00034.870.06643.080.0702
HAR116chr22:41038761-41038863intergenicNONONONONANA0.01930.00014.860.06642.170.1257
HAR117chr18:21008682-21008957intronicNONONOYESNA10.00720.00374.850.06640.720.0127
HAR118chr8:92894694-92894817intergenicNONONOYESNA10.02460.00064.840.06643.330.0107
HAR119chr13:70621912-70622071intergenicNONONONONANA0.01880.01274.830.06642.950.2212
HAR120chr11:130770700-130770847intronicYESNONONONANA0.02060.00074.820.06642.870.0038
HAR121chr11:46999769-46999910intronicNONONONONANA0.02120.00024.800.06643.560.0458
HAR122chr2:59091009-59091235intergenicNONONOYESNA10.01320.00014.790.06641.800.0045
HAR123chr2:205610878-205611015intronicNONONOYESNA10.02240.00104.790.06642.860.0007
HAR124chr7:110340898-110341121intronicNONOYESNONANA0.01790.00914.780.06642.520.0333
HAR125chr7:36799377-36799504intronicNONONONONANA0.02340.00024.780.06643.260.0604
HAR126chr5:165914130-165914280intergenicNONONONONANA0.02000.00034.740.06643.310.0064
HAR127chr7:14264920-14265022intronicNONONONONANA0.02910.00024.740.06643.330.0497
HAR128chr8:92612663-92612808intergenicNONONONONANA0.01360.00014.710.06641.780.0107
HAR129chrX:10817823-10817961intergenicNONONONONANA0.02160.00014.710.06643.750.0171
HAR130chr1:116081270-116081380intergenicNONONONONANA0.01790.00014.710.06642.010.2396
HAR131chr15:84365730-84365831intergenicNONONONONANA0.01950.00014.710.06642.240.1271
HAR132chr9:79020530-79020717intergenicNONONONONANA0.01590.00014.670.06643.150.0051
HAR133chr4:58062491-58062709intergenicNONONONONANA0.01370.00014.670.06643.330.0021
HAR134chr18:70898525-70898935intronicNONONOYESNA10.00730.00014.650.06642.920.0020
HAR135chr16:7114843-7114961intronicNONONONONANA0.02530.00014.650.06643.890.0688
HAR136chr15:59834602-59834726intergenicNONONONONANA0.02400.00024.620.06643.200.0349
HAR137chr13:71239646-71239995intronicNONONOYESNA10.00870.00584.620.06641.700.0046
HAR138chr5:154451746-154451862intergenicNONONOYES00.7910.01710.00874.600.06641.250.2430
HAR139chr5:166553992-166554139intergenicNONONONONANA0.02030.00034.570.06642.720.0038
HAR140chr3:16901645-16901759intergenicNOYESYESNONANA0.02720.00144.570.06643.250.0016
HAR141chrX:106490922-106491083intergenicNONONONONANA0.02470.00024.560.06644.650.0171
HAR142chr10:9282429-9282567intergenicNONONONONANA0.02910.00064.540.06644.550.0178
HAR143chr7:121562740-121563019intronicNONONOYESNA10.00710.00014.530.06641.660.0020
HAR144chr14:32273154-32273357intronicNONOYESNONANA0.01000.00514.530.06640.840.0066
HAR145chr13:70795608-70795752intergenicNONONOYES00.1060.02060.00704.520.06641.940.0840
HAR146chr5:141674679-141674780codingNOYESYESNONANA0.04170.01724.510.06642.790.8378
HAR147chr15:93894709-93894954intergenicNONONOYESNA10.01230.00434.500.06641.870.0021
HAR148chr16:71225210-71225480intergenicNONONOYES00.5880.01110.00004.490.06643.410.0040
HAR149chr7:7585445-7585601intergenicNONOYESNONANA0.01910.00024.470.06643.180.0227
HAR150chr1:190664101-190664211intergenicNONONONONANA0.01790.00014.460.06640.580.3228
HAR151chr3:70137854-70137957intergenicNONONONONANA0.01920.00974.440.06641.330.3275
HAR152chr4:113792449-113792585utrNOYESYESNONANA0.02190.00034.410.06643.130.0458
HAR153chr4:179785147-179785327intergenicNONONOYESNA10.01650.00024.410.06642.800.0090
HAR154chr2:206582547-206582667intergenicNONONONONANA0.01640.00024.400.06641.880.0462
HAR155chr1:161264823-161264941intronicNONOYESYES0.750.0220.01680.00014.400.06642.020.0050
HAR156chr8:116860844-116861004intergenicNONONONONANA0.01240.00014.400.06641.980.0036
HAR157chr2:144547035-144547241intronicNONONOYES0.50.0580.00960.00014.390.06641.740.0019
HAR158chr1:214816880-214817014intergenicNONONONONANA0.01500.00044.390.06642.170.0123
HAR159chr6:22225996-22226174intergenicNONONOYES00.1090.01680.00564.380.06642.490.1010
HAR160chr7:26233368-26233459intronicNONONONONANA0.02180.00024.370.06642.150.2387
HAR161chr8:133880442-133880620intronicNOYESYESNONANA0.02020.00304.360.06641.280.3433
HAR162chr14:25664039-25664320intergenicNONONOYESNA10.01070.00024.350.06642.940.0007
HAR163chr13:71416737-71416920intergenicNONONONONANA0.01640.00034.350.06643.180.0109
HAR164chr1:88248767-88248910intergenicNONONONONANA0.01410.00734.340.06641.080.0122
HAR165chr2:144415280-144415404intergenicNONONONONANA0.01590.00014.290.06641.930.0227
HAR166chr5:79401086-79401232intronicNONONONONANA0.02030.00014.270.06643.360.3259
HAR167chr4:182628483-182628584intergenicNONONONONANA0.03080.00854.270.06644.550.3000
HAR168chr18:34799019-34799190intergenicNONONOYESNA10.01170.00024.270.06641.980.0036
HAR169chr2:177541650-177541811intergenicNONONONONANA0.01870.00034.260.06643.320.0066
HAR170chr7:113788271-113788430intronicNONONONONANA0.01250.00014.250.06641.900.0038
HAR171chr19:36487274-36487445intronicNONONOYESNA10.01770.00054.250.06642.920.0021
HAR172chr11:115429522-115429752intergenicNONONOYESNA10.01330.00494.240.06641.760.0018
HAR173chr14:32830610-32830727intronicNONONONONANA0.01700.00024.220.06642.000.0077
HAR174chr8:66405063-66405226intergenicNONONONONANA0.01230.00634.210.06641.090.0084
HAR175chr18:35547652-35547772intergenicNONONONONANA0.01650.00014.200.06642.100.0227
HAR176chr17:59968931-59969039intergenicNOYESYESNONANA0.01870.00074.200.06641.850.0116
HAR177chr1:213526500-213526742intronicNONONONONANA0.01240.00844.190.06641.480.0027
HAR178chr2:156408625-156408833intergenicNONONOYES0.250.0710.00960.00024.170.06951.560.0002
HAR179chr2:181537192-181537311intergenicNONONONONANA0.02500.00024.160.06953.380.0688
HAR180chr2:60428317-60428480intergenicNONONONONANA0.01220.00624.140.06951.130.0462
HAR181chr11:114304403-114304593intergenicNONONONONANA0.01570.00024.140.06953.000.0087
HAR182chr6:104022646-104022799intergenicNONONONONANA0.01300.00664.130.06951.130.0462
HAR183chr17:5991079-5991300intergenicNONONONONANA0.02030.00744.120.07022.990.0123
HAR184chr9:79780644-79781097intergenicNONONONONANA0.01330.00024.120.07055.450.0002
HAR185chr11:115936629-115936805intergenicNONONOYES00.1690.01140.00574.110.07081.160.0133
HAR186chr4:60890042-60890198intergenicNONONONONANA0.02080.00484.100.07344.480.0233
HAR187chr6:102803961-102804060intergenicNONONONONANA0.02000.00014.100.07342.320.2396
HAR188chr11:115068566-115068692intergenicNONONOYES1.250.0070.01570.00794.090.07341.360.2684
HAR189chr14:32558543-32558772intronicNONONONONANA0.01320.00034.090.07342.890.0021
HAR190chr18:41126009-41126486intergenicNONONOYES0.250.0420.00640.00024.090.07342.480.0000
HAR191chr9:106457811-106458138intergenicNOYESYESYESNA10.00920.00024.070.08082.640.0006
HAR192chr18:41268904-41269069intergenicNONONOYESNA10.01810.00634.060.08081.970.1468
HAR193chr5:145665978-145666106intergenicNONONONONANA0.01540.00014.050.08320.860.0672
HAR194chr2:145068632-145068837intronicNONOYESYES0.250.130.01460.00024.050.08321.200.0107
HAR195chr15:95947065-95947170intergenicNONONONONANA0.02820.00024.040.08643.030.0458
HAR196chr6:19829128-19829249intergenicNONONOYESNA10.01640.00014.030.08642.370.0978
HAR197chr3:28282324-28282513intronicNONOYESNONANA0.01060.00534.030.08721.250.0128
HAR198chr8:37274964-37275221intergenicNONONOYES0.250.3030.01170.00404.020.08742.210.0071
HAR199chr18:35515079-35515206intergenicNONOYESNONANA0.01570.00024.020.08742.460.0317
HAR200chr16:72409359-72409497intergenicNONOYESYES00.2610.02160.00744.010.08741.220.1478
HAR201chr10:16694590-16694747intronicNONONONONANA0.01890.00024.000.08813.190.0227
HAR202chr14:33115320-33115523intronicNONONOYES0.50.3220.00980.00003.990.09122.250.0037
Coordinates: position in hg17 (build 35)
Location: intergenic, intronic, coding, or RNA gene
Last Band: YES=element in distal band of chromosome arm
mRNA: YES=element overlaps a human mRNA
EST: YES=element overlaps a human EST
Evofold
* Structure: YES=element overlaps an Evofold RNA structural prediction
* Statatistic: score for structural compatibility of substitution
* Pvalue: permutation p-value (unadjusted)
Substitution Rates
* Human: expected subs per site on human branch
* Chimp: expected subs per site on chimp branch
Likelihood Ratio Test (LRT)
* Statistic: LRT statistic from 14 species alignments
* Pvalue: simluation p-value (FDR adjusted)
Index of Dispersion
* Statistic: human-chimp-mouse tree, weighted version
* Pvalue: simulation p-value (FDR adjusted)